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Dental Bone Graft Material Company

Orthogen was founded by a group of biomaterials specialists from New York University in 1992. While a division of BioLok International, a publicly held dental products company, Orthogen's founders developed the LaserLok line of dental implants and calcium sulfate-based dental bone graft products. Orthogen LLC was spun off in October 2007 and continues to develop and market bone grafting products for dental and orthopedic applications.

Over a decade of research has enabled Orthogen, LLC to develop a novel, patented nanotechnology based bone graft material, trade-named NanoGen. The research and development was supported by National Institutes of Health through their Small Business Innovation Research (SBIR) program and New Jersey Commission on Science and Technology through its Edison Innovation Program. Orthogen, LLC conducted the research in collaboration with reputed institutes like Rutgers University and New York University School of Dentistry. NanoGen is the first nanotechnology based dental bone graft allowed for marketing by United States Food and Drug Administration. NanoGen undergoes controlled degradation in bone defect and its implantation results in effective bone regeneration. It has been tested clinically for various bone grafting indications in dentistry including infrabony defects, extraction sockets and sinus augmentation cases. Results demonstrated that NanoGen is a highly effective material to treat such cases. The same patented nanotechnology also allows Orthogen, LLC to further develop orthopedic and dental bone regeneration materials with varying degradation profiles. Additionally, Orthogen, LLC continues to sell and promote DentoGen®, a calcium sulfate based dental bone graft material used for several decades in dentistry.


News & Events

NanoGen Launch

NanoGen is a new bone graft product recently launched by Orthogen.



DentoGen Released For Sale

DentoGen is a new bone graft recently launched by orthogen. DentoGen is approved for use as a bone...


Client Testimonials

  • Ziv Mazor, DDS
    Private Practice, Ra'anana, Israel
    NanoGen serves as an excellent bone graft product to treat molar extraction sockets in my patients. Up to 60% new bone was observed in the sockets grafted with NanoGen of which 100% was vital bone.

  • Robert Horowitz, DDS
    Scarsdale, NY
    NanoGen is an intelligently designed nano-particulate graft material. It handles well and resorbs fully leaving the grafted site in an optimal state for bone regeneration.

  • Shankar Iyer, DDS
    Elizabeth, NJ
    I am pleased with the improvements made in Calcium sulfate bone substitutes made by Orthogen. The clinical outcome has been encouraging. This is my material of choice for grafting

  • Ashish Jain BDS, MDS
    Head of Periodontology Department
    I have used NanoGen extensively with great results to treat infrabony defects. NanoGen has helped to stabilize the tooth while regenerating bone in these defect areas

  • Dr. Yoshiharu Komatsu,
    Komatsu Dental Clinic, Kohnan City, Japan
    Very satisfied with NanoGen, easy to use and great quality.

  • Yao-Lin Tang, DDS
    San Mateo, CA
    I have used this bone graft and I really like it because it's so easy to use and you can't beat the price. I have already recommended it to my colleagues.

  • Robert M. Bagoff,
    DMD, FAGD, FICOI Livingston, NJ
    DentoGen® to NanoGen the pathway to better treatment in my clinical practice. In a Type I extraction socket, NanoGen has changed my guided bone regeneration protocol.

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