NanoGen is a proprietary product developed by Orthogen, LLC. Microcrystalline calcium sulfate is converted to grains of calcium sulfate (size range 200 to 900 nanometers), which are tightly compressed together to form granules in sizes ranging from 400 to 1000 microns. This unique microscopic structure imparts unique properties to the product. NanoGen undergoes controlled degradation over a period of 12 weeks as compared to 4 to 6 weeks for traditional calcium sulfate. As it degrades, it leads to the formation of calcium phosphate which is the main inorganic component of bone and which also serves as a stimulus for further bone regeneration. Osteoblasts attach to the calcium phosphate and deposit more bone in the defect.

Since NanoGen degrades over a controlled period as compared to traditional calcium sulfate, it provides the stimulation for bone regeneration over a much longer period. Hence robust bone regeneration is observed in defects grafted with NanoGen.

Because it is completely degradable, bone defects grafted with NanoGen are eventually completely replaced with regenerated vital bone. Research shows that availability of vital bone is important for the placement and eventual success of dental implants.

nanogen bone graft
Histological evidence of bone formation in small defect grafted with NanoGen.


  • As a stand-alone bone graft material
  • In combination with other bone graft materials
  • To provide a resorbable barrier over other bone graft materials

How to Use

Examples of Use

Oral Surgery
Post-extraction: Carefully pack the NanoGen putty into the defect after tooth extraction. Compress the putty to ensure complete filling of the socket.The site can be closed with any of the
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