Scientific Data

  • Biological Mechanisms of Calcium Sulfate Replacement by Bone:
  • Ricci J.L., Alexander H., Nadkarni P., Hawkins M., Turner J., Rosenblum S., Brezenoff L., DeLeonardis D., Pecora G. Bone Engineering, Edited By J. Davies; 2000; 332-344. This paper discusses how calcium sulfate is replaced by bone after being grafted in the bone defect.
  • Bone Regeneration With A Calcium Sulfate Barrier:
    Gabriele Pecora., MD, Sebastiano Andreana, Joseph E. Margarone III, Ugo Covani, John S. Sottosanti. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997;84:424-9).
    This paper discusses the effective use of calcium sulfate as a barrier in female Sprague Dawley rats.
  • Link to Abstract:
  • Bone Regeneration With Calcium Sulfate:
    Evidence For Increased Angiogenesis In Rabbits. Strocchi R, Orsini G, Iezzi G, Scarano A, Rubini C, Pecora G. Journal of Oral Implantology 2002, 28, 5.
  • This study shows the significantly increased presence of micro blood vessels in defects that were grafted with calcium sulfate as compared to those grafted with autograft, indicating the angiogenic properties of calcium sulfate.
  • Link to Abstract:
  • Migration of Human Gingival Fibroblasts Over Guided Tissue Regeneration Barrier Material:
    Payne J, Cobb C, Rapley J, Killoy W, Spencer P. J Periodontol 1996;67:236-244.
    This study discusses and compares the growth of fibroblasts on different barrier membranes (PLA, ePTFE or calcium sulfate) and shows that calcium sulfate is effective as a barrier membrane.
  • Link to Abstract:
  • Response of a Calcium Sulfate Bone Graft Substitute in a Confined Cancellous Defect:
  • Walsh W., Morberg P., Yu Y., Yang Y, Haggard W., Sheath P, Svehla M, and Bruce W. J. M. Clinical Orthopedics and Related Research, 2003; 406: 228-236.
  • This paper discusses the molecular mechanism through which calcium sulfate acts as a bone graft. There was increased local acidity, which led to demineralization of the surface layer of surrounding bone. This led to release of growth factors into the bone defect, which further stimulated bone formation.
  • Link to Abstract:
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